Sigrid working at the lab

Sigrid has defended her Master’s thesis!

We’re so proud to announce that on May 30th, 2023, Sigrid has defended her Master’s thesis titled Optimization of CRISPR-Cas9 Genome Editing in Human PBMCs!

Sigrid’s work at our lab involved improving precise CRISPR editing by local chromatin modulation, and her daily lab supervisor was Pavel.

Sigrid and Pavel
Sigrid and Pavel

I decided to do my master's project in collaboration with NCMM and the Haapaniemi Lab mainly because of CRISPR. I've always been intrigued by this gene editing platform and I was very excited starting in June last year.

One of my research questions was to optimize the precise gene editing in human blood cells by delivering Cas9 as mRNA. I didn't have any knowledge nor experience when it came to handling cell cultures, which actually became one of my favorite techniques in the lab.

I also found bacteria work very relaxing (as long as my colonies survived), and as soon as I mastered the in vitro transcription protocol, I enjoyed synthesizing my own mRNA.

I valued all the time spent in the lab thanks to the excellent training and supervision I received throughout my stay at Haapaniemi Lab. Working in this lab taught me the beauty of science and that a failed experiment fosters valuable feedback and insight when handled correctly.

To be honest, I did several mistakes and errors that I found very embarrassing, nevertheless, these mistakes gave me the drive and motivation to succeed in my next experiments.

During my master's project I achieved both professional and personal growth which I will proudly carry with me in my future endeavors. Thank you for this wonderful journey.

It has been a pleasure working together with Sigrid here at the lab, and we wish her all the best for her future adventures!

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