Our group focuses on developing targeted therapies for rare immunological conditions, such as primary immunodeficiency diseases and immunological conditions of unknown origin.
We aim to optimize the CRISPR-Cas gene editing technology as a gene therapy in these diseases, and stratify the existing therapies – such as biologic drugs and small molecule inhibitors – to better target the underlying molecular pathways that malfunction in individual patients.
We utilise custom genomics and high-throughput screening to understand immune diseases and optimize CRISPR-Cas9 genome editing towards safe and efficient use in patients. We work with cell models and patient material.
Our international team is based at the Centre for Molecular Medicine Norway in Oslo, Norway. We have diverse backgrounds and expertise in biosciences and clinical medicine.
Our main projects involve optimising genome editing, along with personalised use of targeted therapies in rare diseases. We’re interested in rare and undiagnosed immunological diseases.
See our latest studies and research highlights in genome editing and novel genetic etiologies of immunological diseases in chronological order.
Oline’s presentation was titled “CRISPR corrected T-cells for personalized therapy of IEIs.”
Anniken will be working closely with Shiva and Frida on CRISPR gene editing of T cells.
We’re excited to present our newest paper, currently in preprint!
We are proud to be a part of the new Centre of Excellence: The Precision Immunotherapy Alliance (PRIMA).